Aaron Ramsey will miss Wales' opening Euro 2020 qualifier against Slovakia on Sunday after failing to recover from injury.
The 28-year-old – who has signed a pre-contract agreement to join Juventus at the end of the season – has withdrawn from the squad and returned to his club for treatment.
Ramsey played no part in The Dragons' 1-0 friendly win over Trinidad and Tobago on Wednesday.
Wales manager Ryan Giggs said: "It's a blow, especially the form he's been in, but it gives a chance for somebody else.
"We made sure we had a plan B and we've worked on that during the week. We're going to miss someone like Aaron, but we've prepared for it as well."
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